Biography

Dejing PAN earned his PhD degree in Molecular Biomedicine, University of Basel, Switzerland in 2008. Then he worked as a postdoctoral fellow at University Hospital of Basel. In 2012, he worked as deputy Director and research Associate Professor in Model Animal Research Centre of Nanjing University. In 2015, he has served as deputy Director/research associate professor, National Center for International Research of Genomics/CAM-SU Genomic Resource Center of Soochow University.

Research Interests

1. Obesity and its metabolic complications.

2. Metabolism and Immunology in Health Aging.    

Current and past funding

1. Sun Yat-San Univeristy joint fund “Immuno-metabolism study in Aging” (2025-2026),PI:Dejing PAN, 300,000 RMB

2. Cambridge University of Nanjing Center“Obesity associated metabolic complications: Pathogenic mechanisms, diagnostic biomarkers and therapeutic targets and seeks collaboration opportunities with local researchers in China”(2023-2025), PI: Dejing PAN, 2,120,000 RMB

3. China’s National Key Project of “Mouse phenomics of development& metabolism” (2018YFA0801100, 42 Million RMB total, 2019-2024), Co-PI: Dejing Pan assigned with 760,000 RMB

4. National Nature Science Foundation of China (#31771299; 2018-2021) “SR motif’s function in regulation of circadian clock”, PI: Dejing Pan, 720,000 RMB

Selected Publications 

1. Rongchuan Zhao, Jiao Yang, Yunjiao Zhai, Hong Zhang, Yuanshuai Zhou, Lei Hong, Detian Yuan, Ruilong Xia, Yanxiang Liu, Jinlin Pan, Shaheryar Shafi, Guohua Shi, Ruobing Zhang , Dingsan Luo, Jinyun Yuan, Dejing Pan, Changgeng Peng, Shiyang Li, Minxuan Sun. Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity. Nat Immunol . 2024 Sep;25(9):1565-1579

2. You-tian Hu, Zhi-wei Liu, Tong-hui Zhang, Yu-e Ma, Lei He, Jie Zhang, Yue-yang Zhou, Antonio Vidal-Puig, De-jing Pan* & Fang Wu*.  Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase. Acta Pharmacol Sin .  2024 Nov;45(11):2366-2379.

3. Yuanting Zheng*; Bingying Li*; Dejing Pan*; Jun Cao; Jian Zhang; Xiaolin Wang; Xiangnan Li; Wanwan Hou; Ding Bao; Luyao Ren; Jingcheng Yang; Shangzi Wang; Yangyang Qiu; Fei Zhou; Zhiwei Liu; Sibo Zhu; Lei Zhang; Tao Qing; Yi Wang; Ying Yu; Jiaxue Wu; Xichun Hu; leming Shi. Functional Consequences of a Rare Missense BARD1 c.403G>A Germline Mutation Identified in a Triple-Negative Breast Cancer Patient. Breast Cancer Research 2021 May 1;23(1):53 https://doi.org/10.1186/s13058-021-01428-5 (*Co-First Author)

4. Zhen Zhu*, Yingying Wang, Ruobo Peng, Pan Chen, Yangye Geng, Bailiang He, Shuiping Ouyang, Ke Zheng, Yimin Fan, Dejing Pan, Nan Jin, Fabian Rudolf, Andreas Hierlemann,A microfluidic single-cell array for in situ laminar-flow-based comparative culturing of budding yeast cells, Talanta 2021;(231):122401

5. Xingyu Xu, Zhen Zhu, Yingying Wang, Yangye Geng, Feng Xu, Mario A Marchisio, Zixin Wang, Dejing Pan, Investigation of daughter cell dissection coincidence of single budding yeast cells immobilized in microfluidic traps, Anal Bioanal Chem,2021;413(8):2181-2193.

6.  Zhang T, Xie P, Dong Y, Liu Z, Zhou F, Pan D, et al. (2020) High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genet 16(1): e1008577.

7. Kun Jia, Zongyang Lu, Fei Zhou, Zhiqi Xiong,Rui Zhang, Zhiwei Liu, Yu’e Ma, Lei He,Cong Li, Zhen Zhu, Dejing Pan*, Zhengxing Lian*  Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption. Protein & Cell 2019 Nov;10(11):832-839; doi.org/10.1007/s13238-019-0611-6) (Co-corresponding Author)

8. Zhen Zhu *, Yangye Geng, Zhangyi Yuan, Siqi Ren, Meijing Liu, Zhaozheng Meng and Dejing Pan,* A Bubble-Free Microfluidic Device for Easy-to-Operate Immobilization, Culturing and Monitoring of Zebrafish Embryos. Micromachines 2019, Feb;10(3), 168; doi:10.3390/mi10030168. (Co-corresponding Author)

9. Zhen Zhu*, Weijie Chen, Beitong Tian, Yulong Luo, Jianfeng Lan, Di Wu, Di Chen, Zixin Wang and Dejing Pan. Using microfluidic impedance cytometry to measure C. elegans worms and identify their developmental stages Sensors & Actuators: B. Chemical 2018;(275):470-482

10. Ying Xu* & Dejing Pan* Interpretation of the Nobel Prize in Physiology or Medicine Sci China Life Sci 2018,Jan;(61),131–134.

11. Xiao Q, Zhang G, Wang H, Chen L, Lu S, Pan D, Liu G, Yang Z.A p53-based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration. Development. 2017;144(4):580-589

12. Xing L, An Y, Shi G, Yan J, Xie P, Qu Z, Zhang Z, Liu Z, Pan D*, Xu Y*. Correlated evolution between CK1δ Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. J Biol Chem. 2017 Jan 6;292(1):161-171 (co-coresponding Author)

13. Yajie Zhang, Yafeng Wang, Chi Zhang, Jin Wang, Dejing Pan,Jianghuai Liu,Fude Feng, Targeted Gene Delivery to Macrophages by Biodegradable Star-Shaped Polymers ACS Applied Materials & Interfaces 2015;8(6), pp 3719-3724

14. Nie J, Jiang M, Zhang X, Tang H, Jin H, Huang X, Yuan B, Zhang C, Lai JC, Nagamine Y, Pan D, Wang W, Yang Z Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development  Cell Reports 2015, 13(4):723

15. Pan D, Schomber T, Kalberer CP, Terracciano LM, Hafen K, Krenger W, Hao-Shen H, Deng C, Skoda RC.“ Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice.“ Blood. 2007;15;110(8):3049-55.

16. Lai J, Ponti S, Pan D, Kohler H, Skoda RC, Matthias P, Nagamine Y.“The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis “Blood. 2012; 119:4291-300

Current Post-Graduate students’ Mentorship:

Xi YANG, Xiaorui XIE, Ji XU, Wenqiu WANG, Dongdong WANG, Kamran Arif, Fizza Anwar, Hasfa Gul