Biography

Fei Zhou received his Bachelor's degree from Life Sciences Department of Nanjing University (2006) and Ph.D. degree in Biology from Model Animal Research Center of Nanjing University (2011). He then worked as a senior scientist in WuXi AppTec (2011-2014) and is now an associate professor of CAM-SU Genomic Resource Center, Soochow University. He has undertaken several projected funded by the National Natural Science Foundation of China and the Natural Science Foundation of Jiangsu Province, as well as the Natural Science Foundation of the Jiangsu Higher Eduction Institutiuon. He also participated in multiple projectes funded by the National Key R&D Program of China.

Research Interests

Gene editing tools are powerful instruments in modern biomedical research. The development of gene editing tools has greatly advanced the study of gene function and the progress of gene therapy for genetic diseases. Our group closely follows the latest developments of gene editing tools, with a special focus on base editing. We are dedicated to developing new gene editing tools, including those targeting the mitochondrial genome (mtDNA). We are also actively working on establishing disease animal models using gene editing techniques. With established disease models, we are trying to explore gene editing-based therapeutic strategies. In addition, our group also studies the correlation between circadian rhythms and physiological homeostasis.

Selected Publications

1. Guo J^#, Chen X^#, Liu Z^#, Sun H^#, Zhou Y, Dai Y, Ma Y, He L, Qian X, Wang J, Zhang J, Zhu Y, Zhang J*, Shen B* and Zhou F*. DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome. Molecular Therapy – Nucleic Acids. 2022;27:73-80

2. Zhang T^#, Du X^#, Gu Y^#, Dong Y^#, Zhang W, Yuan Z, Huang X, Zou X, Zhou Y, Liu Z, Tao H, Yang L, Wu G, Hogenesch J, Zhou C, Zhou F* and Xu Y* Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine. Frontiers in Physiology. 2022;13.

3. Wang X^#, Liu Z^#, Li G^#, Dang L, Huang S, He L, Ma Y, Li C, Liu M, Yang G, Huang X, Zhou F* and Ma X*. Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation. Molecular Therapy. 2020;28:431-440

4. Jia K^#, Lu Z^#, Zhou F^#, Xiong Z, Zhang R, Liu Z, Ma Y, He L, Li C, Zhu Z, Pan D* and Lian Z*. Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption. Protein & Cell. 2019;10:832-839.

5. Wang L^#, Zhou F^#, Zhang P^#, Wang H, Qu Z, Jia P, Yao Z, Shen G, Li G, Zhao G, Li J, Mao Y, Xie Z, Xu W, Xu Y*, Xu Y*. Human Type H Vessels are a Sensitive Biomarker of Bone Mass. Cell Death & Disease. 2017;8, e2760

6. Shen B^#, Shang Z^#, Wang B^#, Zhang L^#, Zhou F^#, Li T, Chu M, Jiang H, Wang Y, Qiao T, Zhang J, Sun W, Kong X, He Y*. Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34:1221-1230

7. Zhou F^#, Chang Z^#, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z*, He Y*. Akt/protein kinase b is required for lymphatic network formation, remodeling, and valve development. The American Journal of Pathology. 2010;177:2124-2133

8. Zhang L^#, Zhou F^#, Han W^#, Shen B, Luo J, Shibuya M, He Y*. Vegfr-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Research. 2010;20:1319-1331