教育经历

2014/09-2020/09     加利福尼亚大学戴维斯分校，昆虫学，理学博士学位

2010/09-2014/07     北京林业大学，生物科学，理学学士学位

工作经历

2024/11至今            苏州大学，剑桥苏大基因组资源中心，副教授，优秀青年学者

2020/10-2024/10     加利福尼亚大学戴维斯分校，昆虫学、药学，联合培养博士后

研究方向

主要围绕生物体如何调控昼夜节律的关键科学问题，从蛋白质翻译后修饰层面探索饮食行为调控生理节律的分子机制，具体研究蛋白质O-GlcNAc糖基化调控生理节律及其与饮食和生物钟之间的相互作用。近年来，以第一（共一）作者在PNAS (2024)、Nat Commun (2021)、JBC (2023)等期刊发表多篇工作成果。

代表性著作

1. Xianhui Liu, Yao D Cai, Chunyan Hou, Xu Liu, Youcheng Luo, Aron Judd P. Mendiola, Xuehan Xu, Yige Luo, Haiyan Zheng, Caifeng Zhao, Ching-Hsuan Chen, Yong Zhang, Yang K. Xiang, Junfeng Ma, Joanna C. Chiu. (2025) Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression. Plos Biology (Accepted).
2. Xu Liu, Ya Huang, Jiajia Fang, Xianli He, Yue Zhou, Wei Luan, Xianhui Liu, Yong Zhang. (2025) RTF1 enhances CLK occupancy and histone methylation at key circadian clock pacemaker gene loci. Journal of Cell Biology (Accepted).
3. Yao Cai, Xianhui Liu, Gary K Chow, Sergio Hidalgo, Kiya C Jackson, Cameron D Vasquez, Zita Y Gao, Vu Lam, Christine A Tabuloc, Haiyan Zheng, Caifeng Zhao, Joanna C. Chiu. (2024) Alternative splicing of Clock transcript mediates the response of circadian clocks to temperature changes. PNAS 121(50):e2410680121. (Co-first author)
4. Ying Wang, Meimi Zhao, Xianhui Liu, Bing Xu, Gopireddy R. Reddy, Aleksandra Jovanovic, Qingtong Wang, Chaoqun Zhu, Heli Xu, Elizabeth F. Bayne, Wenjing Xiang, Douglas G. Tilley, Ying Ge, Christopher G. Tate, Robert Feil, Joanna C. Chiu, Donald M. Bers, Yang K. Xiang. (2024) Carvedilol activates a myofilament signaling circuitry to restore cardiac contractility in heart failure. JACC: Basic to Translational Science 9(8):982-1001.
5. Xianhui Liu, Yao D. Cai, and Joanna C. Chiu. (2023) Metabolic and non-metabolic regulation of protein O-GlcNAcylation. Journal of Biological Chemistry 12(9):220215.
6. Bingqing Deng, Yu Zhang, Chaoqun Zhu, Ying Wang, Eric Weatherford, Bing Xu, Xianhui Liu, Simon J Conway, E. Dale Abel, Yang K Xiang. (2023) Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling. Circulation Research 132(1):106-108.
7. Xianhui Liu, and Joanna C. Chiu (2022) Nutrient-sensitive post-translational modifications shape daily physiological rhythms. Open Biology 12(9):220215.
8. Xianhui Liu, Ivana Blaženović, Adam J. Contreras, Thu M. Pham, Christine A. Tabuloc, Ying H. Li, Jian Ji, Oliver Fiehn, and Joanna C. Chiu (2021) Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation. Nature Communications 12(1): 4173.
9. Qike Wang, Genting Liu, Liping Yan, Wentian Xu, Douglas J Hilton, Xianhui Liu, Wenya Pei, Xinyu Li, Jinbiao Wu, Haifeng Zhao, Dong Zhang, Mark A Elgar (2023). Short-term particulate matter contamination severely compromises insect antennal olfactory perception. Nature Communications 14(1):4112.
10. Yao D. Cai, Yongbo Xue, Cindy Truong, Jose Del-Carmen Li, Christopher Ochoa, Jens T. Vanselow, Katherine A. Murphy, Ying H. Li, Xianhui Liu, Ben L. Kunimoto, Haiyan Zheng, Caifeng Zhao, Yong Zhang, Andreas Schlosser, Joanna C. Chiu (2021) CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythms. Current Biology 31(3): 502-514.e7.
11. Ying H. Li, Xianhui Liu, Jens T. Vanselow, Haiyan Zheng, Andreas Schlosser, Joanna C. Chiu (2019) O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression. PLoS Genetics 15(1): e1007953.
12. Vu H. Lam, Ying H. Li, Xianhui Liu, Katherine A. Murphy, Jonathan S. Diehl, Rosanna S. Kwok and Joanna C. Chiu (2018) CK1α collaborates with DOUBLETIME to regulate PERIOD function in the Drosophila circadian clock. Journal of Neuroscience 38 (50): 10631-10643.

联系方式

电话：13455611744      邮箱：xhliu@suda.edu.cn